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1

Synthesis and Antimycobacterial Activity of Capuramycin Analogues. Part 1. Substitution of the Azepan-2-one Moiety of Capuramycin.

Hitoshi Hotoda, et al. et al.

Journal:

Year:

2003

File:

PDF, 73 KB

2003

2

Synthesis and Antimycobacterial Activity of Capuramycin Analogues. Part 2. Acylated Derivatives of Capuramycin-Related Compounds.

Hitoshi Hotoda, et al. et al.

Journal:

Year:

2003

File:

PDF, 84 KB

2003

3

A new class of condensing reagents for rapid internucleotide bond formation in the phosphotriester approach and preparation of n3-benzoylthymidine as a key intermediate in oligodeoxyribonucleotide synthesis

Jun-ichi Matsuzaki, Hitoshi Hotoda, Mitsuo Sekine, Tujiaki Hata

Journal:

Tetrahedron Letters

Year:

1984

Language:

english

File:

PDF, 265 KB

english, 1984

4

IP3 receptor-ligand. 1: Synthesis of adenophostin A

Hitoshi Hotoda, Masaaki Takahashi, Kazuhiko Tanzawa, Shuji Takahashi, Masakatsu Kaneko

Journal:

Tetrahedron Letters

Year:

1995

Language:

english

File:

PDF, 198 KB

english, 1995

5

A Raman spectroscopic analysis of the sequence-dependent structures of oligo-DNA duplexes: d(CGCG)2, d(GCGC)2, d(GGCC)2, and d(CCGG)2 in aqueous solution

Chikako Torigoe, Yoshifumi Nishimura, Masamichi Tsuboi, Jun-ichi Matsuzaki, Hitoshi Hotoda, Mitsuo Sekine, Tsujiaki Hata

Journal:

Spectrochimica Acta Part A: Molecular Spectroscopy

Year:

1986

Language:

english

File:

PDF, 641 KB

english, 1986

6

Synthesis of cytidyl(3'-5')adenosine bearing 2'(3')-O-leucyl ester via a phosphorothioate triester intermediate

Hitoshi Hotoda, Ryuichi Saito, Mitsuo Sekine, Tsujiaki Hata

Journal:

Year:

1990

Language:

english

File:

PDF, 733 KB

english, 1990

7

Self-complementary tetradeoxyribonucleoside triphosphates convenient chemical preparation and spectroscopic studies in solution

Jun-ichi Matsuzaki, Hitoshi Hotoda, Mitsuo Sekine, Tsujiaki Hata, Shigesada Higuchi, Yoshifumi Nishimura, Masamichi Tsuboi

Journal:

Year:

1986

Language:

english

File:

PDF, 1.11 MB

english, 1986

8

2-cyanoethyl nucleoside 3′-phosphonates as a novel starting materials for oligonucleotide synthesis

Takeshi Wada, Hitoshi Hotoda, Mitsuo Sekine, Tsujiaki Hata

Journal:

Tetrahedron Letters

Year:

1988

Language:

english

File:

PDF, 213 KB

english, 1988

9

Bis (2,4,6-trihalophenoxy) trichlorophosphoranes: Novel condensing reagents for internucleotidic phosphotriester bond formation via active phosphorochloridate intermediates

Jun-ichi Matsuzaki, Hitoshi Hotoda, Mitsuo Sekine, Tsujiaki Hata

Journal:

Tetrahedron Letters

Year:

1986

Language:

english

File:

PDF, 180 KB

english, 1986

10

Tris(2,4,6-tribromophenoxy) dichlorophosphorane: A novel condensing agent for rapid internucleotidic bond formation in the phosphotriester approach

Hitoshi Hotoda, Takeshi Wada, Mitsuo Sekine, Tsujiaki Hata

Journal:

Tetrahedron Letters

Year:

1987

Language:

english

File:

PDF, 235 KB

english, 1987

11

Studies on the synthesis of nucleotidyl-peptide. I: A facile synthesis involving selective PS bond cleavage

Hitoshi Hotoda, Yoshihito Ueno, Mitsuo Sekine, Tsujiaki Hata

Journal:

Tetrahedron Letters

Year:

1989

Language:

english

File:

PDF, 241 KB

english, 1989

12

Synthesis and antimycobacterial activity of capuramycin analogues. Part 2: acylated derivatives of capuramycin-related compounds

Hitoshi Hotoda, Makiko Daigo, Miyuki Furukawa, Kazuhiro Murayama, Chikako Akiyama Hasegawa, Masakatsu Kaneko, Yasunori Muramatsu, Michiko Miyazawa Ishii, Shun-ichi Miyakoshi, Toshio Takatsu, Masatoshi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 194 KB

english, 2003

13

Synthesis and antimycobacterial activity of capuramycin analogues. Part 1: substitution of the azepan-2-one moiety of capuramycin

Hitoshi Hotoda, Miyuki Furukawa, Makiko Daigo, Kazuhiro Murayama, Masakatsu Kaneko, Yasunori Muramatsu, Michiko Miyazawa Ishii, Shun-ichi Miyakoshi, Toshio Takatsu, Masatoshi Inukai, Masayo Kakuta, To

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 174 KB

english, 2003

14

Biologically active oligodeoxyribonucleotides—IX.1 Synthesis and anti-HIV-1 activity of hexadeoxyribonucleotides, TGGGAG, bearing 3′- and 5′-end-modification

Makoto Koizumi, Rika Koga, Hitoshi Hotoda, Kenji Momota, Toshinori Ohmine, Hidehiko Furukawa, Toshinori Agatsuma, Takashi Nishigaki, Koji Abe, Toshiyuki Kosaka, Shinya Tsutsumi, Junko Sone, Masakatsu

Journal:

Bioorganic & Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 783 KB

english, 1997

15

Biologically active oligodeoxyribonucleotides. Part 11: The least phosphate-modification of quadruplex-forming hexadeoxyribonucleotide TGGGAG, bearing 3′- and 5′-end-modification, with anti-HIV-1 activity

Makoto Koizumi, Rika Koga, Hitoshi Hotoda, Toshinori Ohmine, Hidehiko Furukawa, Toshinori Agatsuma, Takashi Nishigaki, Koji Abe, Toshiyuki Kosaka, Shinya Tsutsumi, Junko Sone, Masakatsu Kaneko, Satosh

Journal:

Bioorganic & Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 675 KB

english, 1998

16

The limitation of staged repair in the surgical management of congenital complex heart anomalies with aortic arch obstruction

Ryo Aeba, Toshiyuki Katogi, Kenichi Hashizume, Yoshimi Iino, Kiyoshi Koizumi, Kentaro Hotoda, Shinya Inoue, Hideki Matayoshi, Akihiro Yoshitake, Ryohei Yozu

Journal:

General Thoracic and Cardiovascular Surgery

Year:

2003

Language:

english

File:

PDF, 808 KB

english, 2003

17

Atrophic degeneration and loss of myocytes of residual left ventricular myocardium after Dor operation for ischemic cardiomyopathy associated with left ventricular remodeling

Kiyokazu Kokaji, Masahiko Okamoto, Kentaroh Hotoda

Journal:

General Thoracic and Cardiovascular Surgery

Year:

2003

Language:

english

File:

PDF, 552 KB

english, 2003

18

Changes in left ventricular volume and predictors of cardiac events after endoventricular circular patch plasty

Kiyokazu Kokaji, Hankei Shin, Kentaro Hotoda, Mitsuharu Mori, Hiroya Kumamaru, Ryohei Yozu

Journal:

General Thoracic and Cardiovascular Surgery

Year:

2004

Language:

english

File:

PDF, 668 KB

english, 2004

19

Efficacy of endoventricular circular patch plasty

Kiyokazu Kokaji, Masahiko Okamoto, Kentaro Hotoda, Tadaaki Maehara, Hiroya Kumamaru, Kiyoshi Koizumi

Journal:

General Thoracic and Cardiovascular Surgery

Year:

2004

Language:

english

File:

PDF, 765 KB

english, 2004

20

Surgical management of congenital tracheal stenosis

Masatsugu Terada, Kentaro Hotoda, Miki Toma, Seiichi Hirobe, Shoichiro Kamagata

Journal:

General Thoracic and Cardiovascular Surgery

Year:

2009

Language:

english

File:

PDF, 536 KB

english, 2009

21

Alzheimer Amyloid α-Secretase: A Special Target for Drug Development

Shoichi Ishiura, Nika Hotoda, Beáta Szabó, Masashi Asai, Chinatsu Hattori, Eiichiro Tanaka, Hisashi Koike, Noboru Sasagawa

Journal:

Psychogeriatrics

Year:

2001

Language:

english

File:

PDF, 337 KB

english, 2001

22

ChemInform Abstract: A Novel Carbon-Carbon Bond Formation at the C4 Position of β- Lactams. Fluoride Ion Induced Desilylative α-Hydroxyalkylation of 3-Alkylidene-4-trimethylsilylazetidin-2-ones with Aldehydes.

K. HOTODA, M. AOYAGI, T. TAKANAMI, K. SUDA

Journal:

Year:

1996

File:

PDF, 31 KB

1996

23

Protection of hu-PBL-SCID/beige mice from HIV-1 infection by a modified oligonuleotide, RKS-1443

T. Agatsuma, H. Furukawa, K. Abe, R. Koga, M. Koizumi, H. Hotoda, K. Momota, T. Ohmine, T. Nishigaki, M. Kaneko, S. Kimura, K. Shimada

Journal:

Antiviral Research

Year:

1996

Language:

english

File:

PDF, 118 KB

english, 1996

24

Protection of hu-PBL-SCID/beige mice from HIV-1 infection by a 6-mer modified oligonucleotide, R-95288

Toshinori Agatsuma, Kohji Abe, Hidehiko Furukawa, Rika Koga, Makoto Koizumi, Hitoshi Hotoda, Masakatsu Kaneko

Journal:

Antiviral Research

Year:

1997

Language:

english

File:

PDF, 321 KB

english, 1997

25

ADAM19 is tightly associated with constitutive Alzheimer’s disease APP α-secretase in A172 cells

Chiaki Tanabe, Nika Hotoda, Noboru Sasagawa, Atsuko Sehara-Fujisawa, Kei Maruyama, Shoichi Ishiura

Journal:

Biochemical and Biophysical Research Communications

Year:

2007

Language:

english

File:

PDF, 431 KB

english, 2007

26

ADAM19 autolysis is activated by LPS and promotes non-classical secretion of cysteine-rich protein 2

Chiaki Tanabe, Nika Hotoda, Noboru Sasagawa, Eugene Futai, Hiroto Komano, Shoichi Ishiura

Journal:

Biochemical and Biophysical Research Communications

Year:

2010

Language:

english

File:

PDF, 453 KB

english, 2010

27

A secreted form of human ADAM9 has an α-secretase activity for APP

Nika Hotoda, Hisashi Koike, Noboru Sasagawa, Shoichi Ishiura

Journal:

Biochemical and Biophysical Research Communications

Year:

2002

Language:

english

File:

PDF, 1.54 MB

english, 2002

28

Biologically Active Oligodeoxyribonucleotides. 5. 1 5‘-End-Substituted d(TGGGAG) Possesses Anti-Human Immunodeficiency Virus Type 1 Activity by Forming a G-Quadruplex Structure

Hotoda, Hitoshi, Koizumi, Makoto, Koga, Rika, Kaneko, Masakatsu, Momota, Kenji, Ohmine, Toshinori, Furukawa, Hidehiko, Agatsuma, Toshinori, Nishigaki, Takashi, Sone, Junko, Tsutsumi, Shinya, Kosaka, T

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 209 KB

english, 1998

29

IP3 Receptor-Ligand. 1: Synthesis of Adenophostin A

Journal:

Tetrahedron Letters

Year:

1995

Language:

english

File:

PDF, 198 KB

english, 1995

30

Molecular Recognition of Adenophostin, a Very Potent Ca 2+ Inducer, at the d - myo -Inositol 1,4,5-Trisphosphate Receptor ‡

Hotoda, Hitoshi, Murayama, Kazuhiro, Miyamoto, Shuichi, Iwata, Yoriko, Takahashi, Masaaki, Kawase, Yumi, Tanzawa, Kazuhiko, Kaneko, Masakatsu

Journal:

Year:

1999

Language:

english

File:

PDF, 295 KB

english, 1999

31

Electrochemical fluorination of 4-trimethylsilylazetidin-2-ones: an efficient and regioselective preparation of 4-fluoroazetidin-2-ones

Suda, Kohji, Hotoda, Katsumi, Aoyagi, Mitsuaki, Takanami, Toshikatsu

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1995

Language:

english

File:

PDF, 305 KB

english, 1995

32

A novel synthetic intermediate in ?-lactam chemistry: an efficient preparation of cis-1,3,4-tris(trimethylsilyl)azetidin-2-one and its transformation into 4-acetoxy-3-alkylideneazetidin-2-ones

Suda, Kohji, Hotoda, Katsumi, Iemuro, Fumiaki, Takanami, Toshikatsu

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1993

Language:

english

File:

PDF, 336 KB

english, 1993

33

An efficient and regioselective preparation of 4-oxyazetidin-2-ones from 4-trimethylsilylazetidin-2-ones by use of anodic oxidation

Suda, Kohji, Hotoda, Katsumi, Watanabe, Jun-ichi, Shiozawa, Kei, Takanami, Tosnikatsu

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1992

Language:

english

File:

PDF, 244 KB

english, 1992

34

Biologically Active Oligodeoxyribonucleotides. VII. Anti-HIV-1 Activity of Hexadeoxyribonucleotides Bearing 3′- and 5′-End-Modifications

Koizumi, Makoto, Koga, Rika, Hotoda, Hitoshi, Momota, Kenji, Ohmine, Toshinori, Furukawa, Hidehiko, Nishigakit, Takashi, Abe, Koji, Kosaka, Toshiyuki, Kaneko, Masakatsu, Kimura, Satoshi, Shimada, Kaor

Journal:

Nucleosides and Nucleotides

Year:

1997

Language:

english

File:

PDF, 220 KB

english, 1997

35

A Raman Spectroscopic Study on Conformations of DNA Oligomers: A Dominant Effect of an AA:TT Sequence Over Those of AT:AT and TA:TA Sequences on Determining Conformations of DNA Duplexes

Katahira, Masato, Nishimura, Yoshifumi, Tsuboi, Masamichi, Matsuzaki, Jun-ichi, Hotoda, Hitoshi, Sekine, Mitsuo, Hata, Tsujiaki

Journal:

Nucleosides and Nucleotides

Year:

1994

Language:

english

File:

PDF, 644 KB

english, 1994

36

P-S Bond Formation Between Deoxyribonucleoside Phosphodiesters and Thiols By Means of Btcp

Sekine, Mitsuo, Hotoda, Hitoshi, Matsuzaki, Junichi, Hata, Tsujiaki

Journal:

Natural Product Letters

Year:

1993

Language:

english

File:

PDF, 368 KB

english, 1993

37

Biologically Active Oligodeoxyribonucleotides - II 1 : Structure Activity Relationships of Anti-HIV-1 Pentadecadeoxyribonucleotides Bearing 5′-End-Modifications

Hotoda, Hitoshi, Momota, Kenji, Furukawa, Hidehiko, Nakamura, Takemichi, Kaneko, Masakatsu, Kimura, Satcshi, Shimada, Kawu

Journal:

Nucleosides and Nucleotides

Year:

1994

Language:

english

File:

PDF, 1.02 MB

english, 1994

38

Biologically Active Oligodeoxyribonucleotides - IV : Anti-HIV-1 Activity of Tgggag Having Hydrophobic Substituent at Its 5'-End via Phosphodiester Linkage

Hotoda, Hitoshi, Koizumi, Makoto, Koga, Rika, Momota, Kenji, Ohmine, Toshinori, Furukawa, Hidehiko, Nishigaki, Takashi, Kinoshita, Takeshi, Kaneko, Masakatsu, Kimura, Satoshi, Shimada, Kaoru

Journal:

Nucleosides Nucleotides & Nucleic Acids

Year:

1996

Language:

english

File:

PDF, 407 KB

english, 1996

39

Anti-Human Immunodeficiency Virus Type 1 Activity of R-95288, a Phosphodiester Hexadeoxyribonucleotide Modified by Dibenzyloxybenzyl and Hydroxyethyl Residues at the 5'- and 3'-Ends

Agatsuma, T., Furukawa, H., Hotoda, H., Koizumi, M., Koga, R., Kaneko, M.

Journal:

Antiviral Chemistry & Chemotherapy

Year:

1997

Language:

english

File:

PDF, 702 KB

english, 1997

40

Biologically Active Oligodeoxyribonucleotides. X. Anti-HIV-1 Activity and Stability of Modified Hexanucleotides Containing Glycerol-Skeleton

Hotoda, Hitoshi, Koizumi, Makoto, Ohmine, Toshinori, Furukawa, Hidehiko, Nishigaki, Takashi, Abe, Koji, Kosaka, Toshiyuki, Tsutsumi, Shinya, Sone, Junko, Kaneko, Masakatsu, Kimura, Satoshi, Shimada, K

Journal:

Nucleosides Nucleotides & Nucleic Acids

Year:

1998

Language:

english

File:

PDF, 512 KB

english, 1998

41

Pre−activation strategy for oligodeoxyribonudeotide synthesis using triaryloxydichloro−phosphoranes in the phosphotriester method

Hotoda, Hitoshi, Wada, Takeshi, Sekine, Mitsuo, Hata, Tsujiaki

Journal:

Nucleic Acids Research

Year:

1989

Language:

english

File:

PDF, 1.04 MB

english, 1989

42

[IEEE Asia Pacific Conference and Exhibition of the IEEE-Power Engineering Society on Transmission and Distribution - Yokohama, Japan (6-10 Oct. 2002)] IEEE/PES Transmission and Distribution Conference and Exhibition - Study on aging property of hydrophobic epoxy system for outdoor insulation

Urabe, S., Yoshihara, S., Shirakashi, T., Hotoda, Y.

Year:

2002

Language:

english

File:

PDF, 257 KB

english, 2002

43

Characterization of Recombinant Human DNA Topoisomerase III Activity Expressed in Yeast

Hotoda, N., Hanai, R.

Journal:

Journal of Biochemistry

Year:

2000

Language:

english

File:

PDF, 6.68 MB

english, 2000

44

ChemInform Abstract: Bis(2,4,6-trihalophenoxy)trichlorophosphoranes: Novel Condensing Reagents for Internucleotidic Phosphotriester Bond Formation via Active Phosphorochloridate Intermediates.

MATSUZAKI, J., HOTODA, H., SEKINE, M., HATA, T.

Journal:

Year:

1987

File:

PDF, 87 KB

1987

45

ChemInform Abstract: Tris(2,4,6-tribromophenoxy)dichlorophosphorane: A Novel Condensing Agent for Rapid Internucleotidic Bond Formation in the Phosphotriester Approach.

HOTODA, H., WADA, T., SEKINE, M., HATA, T.

Journal:

Year:

1987

File:

PDF, 80 KB

1987

46

ChemInform Abstract: Synthesis of Cytidyl(3′-5′)adenosine Bearing 2′(3′)-O-Leucyl Ester via a Phosphorothioate Triester Intermediate.

HOTODA, H., SAITO, R., SEKINE, M., HATA, T.

Journal:

Year:

1990

File:

PDF, 81 KB

1990

47

ChemInform Abstract: 2-Cyanoethyl Nucleoside 3′-Phosphonates as Novel Starting Materials for Oligonucleotide Synthesis.

WADA, T., HOTODA, H., SEKINE, M., HATA, T.

Journal:

Year:

1989

File:

PDF, 72 KB

1989

48

Bis (2,4,6-Tribromophenyl) Phosphorochloridate: A New Type of Condensing Reagent in Oligonucleotide Synthesis

Matsuzaki, Jun-Ichi, Hotoda, Hitoshi, Sekine, Mitsuo, Hata, Tsujiaki

Journal:

Nucleosides and Nucleotides

Year:

1989

Language:

english

File:

PDF, 693 KB

english, 1989

49

A Permanent Epicardial Pacemaker Lead That Penetrated the Esophageal Wall 26 years After Implantation

Inoue, Shinya, Hashizume, Kenichi, Koizumi, Kiyoshi, Hotoda, Kentaro, Shinozaki, Hiroharu

Journal:

The Annals of Thoracic Surgery

Year:

2016

Language:

english

File:

PDF, 503 KB

english, 2016

50

Synthesis of 2′(3′)-O-(L-Phenylalanyl) and 2′(3′)-O-(D-Phenylalanyl) Cytidylyl(3′-5′)adenosine

Ueno, Yoshihito, Mishima, Tamako, Hotoda, Hitoshi, Hata, Tsujiaki

Journal:

Chemistry Letters

Year:

1992

File:

PDF, 358 KB

1992